Investigators are studying the
influence of genetic background on thyroid and gonadal function.
PhysGen sends blood samples from the parental rats strains to
the University of Chicago - Roy E. Weiss, M.D., Ph.D., Samuel
Refetoff, M.D., Ph.D., Neal Scherberg and Xiao Hui Liao. Initiated
Differences have been observed in the parental strains therefore,
the study is expanding to include the consomic strains.
Click for initial study results: Summary
of Rat Serum Values and Thyroid
Rat Data (Microsoft documents).
Investigators are studying cardiovascular phenotypes that have been mapped to chromosomal regions
PhysGen has sent tissue samples from hearts in several consomic strains and parentals to Dr. Stuart Cook, Imperial College Faculty of Medicine, Hammersmith Hospital. As results from this collaboration are available, additional information will be posted on the PhysGen website.
Investigators are studying chromosomal
regions and/or genes responsible for the development of an asthmatic
phenotype in consomic rats.
PhysGen sends spleen samples from the consomic and parental rat
strains to the University of Wisconsin Medical School - Louis
Rosenthal, Ph.D., Robert Lemanske, Jr., M.D. and Ronald Sorkness,
Ph.D. Initiated 07/01. You can download the summary slide presentation
of the initial studies by PPT
format (625K) or PDF
The scientific community was
requested to provide input on what rat strains they believe PhysGen
should phenotype ...
... to add to the scientific value of the program. There were
many responses that the steering committee considered. The following
four strains from CRL were selected as the best fit with the program
direction: Lewis LEW/CrlBR, Fischer CDF (F-344) CrlBR, WKY WKY/NCrlBR
and the CD® IGS Crl:CD® (SD)IGS BR. These strains started
through phenotyping 02/02. There were also requests for Brown
Norway, Harlan Sprague Dawley® and SHR rats. These strains
were already part of the ongoing program.
Education & Training Programs
Medical College of Wisconsin
Rat Genome Database
National Heart, Lung, and Blood
The Institute for Genomic Research
RGD Rat Nomenclature