Strain & Genotype Data Description


The SS and BN strains were chosen because of their relevance to hypertension, cardiac and vascular disorders, hyperlipidemia, renal disease and insulin resistance. The SS and BN strains are the parentals for developing the SS.BN consomics. The SS.BN consomics provide a means to validate the mapping studies, generate new genetic mapping data and most importantly will provide the community with renewable animal resources that allow rapid narrowing of genomic regions of interest and ultimate linking of genes to functional pathways of importance to the NHLBI. The FHH strain both complements and contrasts with the SS with respect to heart, lung and blood function. The FHH.BN consomics will be developed later in the program from the FHH and BN parental strains. The SPRD is an outbred rat commonly used in the scientific community. The GH Genetically Hypertensive Rat is an inbred rat that develops hypertension, cardiac hypertrophy and vascular disease. In a complete panel of consomic rats, each chromosome is replaced one at a time (strain A to strain B), so that the contribution of genes on each chromosome can be assessed by phenotyping the consomic strain for the traits of interest on an inbred background. Consomic strains overcome the confounding effects of heterogeneous genomic backgrounds in which the phenotypic noise may make the detection of weak QTLs difficult. Consomics also provide a renewable source of animals and a platform upon which subsequent genetic studies and/or physiological studies can be used to study a QTL on the chromosome.

Click here for the marker sets used in classifying strains as consomic or congenic. (Note that unless otherwise indicated, regions outside these markers have not been characterized.)

Nomenclature Links

RGD Rats Nomenclature Standards

JAX Rat Nomenclature Standards

RGD Genome Scanner


Strain NameStrain DescriptionStrain TypeReferences & Links
BNBrown Norway; BN/NHsdMcwi.PARENTAL
  • Genotype test result
  • RGD BN strain report
  • SSDahl Salt-Sensitive; SS/JrHsdMcwi.PARENTAL
  • Genotype test result
  • RGD SS strain report
  • FHHFawn-Hooded Hypertensive; FHH/EurMcwi.PARENTAL
  • Genotype test result
  • RGD FHH strain report
  • LEWLewis (LEW/CrlBR) Charles River Laboratories.INBRED
  • Detailed genotype of the region.
  • RGD LEW strain report
  • CDFFischer CDF(F-344)CrlBR Charles River Laboratories.INBRED
  • Detailed genotype of the region.
  • RGD CDF strain report
  • CD®IGSCD. IGS (Crl:CD. (SD)IGS BR) Charles River LaboratoriesOUTBRED
  • RGD CD®IGS strain report
  • GHGH Genetically Hypertensive Rats. The MCW colony was derived from the University of Otago colony, registered pure line GH/Omr (Festing MFW. 1979. Inbred Strains in Biomedical Research. Macmillan London) as described originally by Smirk [Smirk FH and Hall WH (1958) Inherited hypertension in rats. Nature (London). 182:727-8].INBRED
  • Genotype test result
  • RGD GH strain report
  • LE/BluGillThis inbred colony from the University of Illinois at Urbana-Champaign was derived from Long Evans Outbred rats originally purchased from Blue Spruce Farms, Altamont, NY in the Fall of 1982. In order to reduce individual differences, Principal Investigator, Martha U. Gillette, PhD, initiated inbreeding (consecutive brother-sister matings). In March 1993, the colony reached generation #20, defined by the Institute for Animal Laboratory Research (ILAR) as the point during inbreeding at which the strain can officially be considered inbred. This inbred colony continues to be used by Dr. Gillette and her laboratory at the University of Illinois at Urbana-Champaign to research cell, molecular and integrative mechanisms in the brain's circadian clock.INBRED
  • Genotype Test Result
  • RGD LE/BluGill strain report
  • SHRSpontaneously Hypertensive Rat;SHR/NCrlBR.INBRED
  • Genotype test result
  • RGD SHR rat strain report
  • SD/HsdHsd:Sprague DawleyOUTBRED
  • RGD SD/Hsd rat strain report
  • WKYWKY/NCrlBR Charles River Laboratories.INBRED
  • Genotype test result
  • RGD WKY strain report
  • SS-1BN/McwiA SS genomic background with a BN chromosome 1 introgressedCONSOMIC
  • Genotype test result
  • SS-2BN/McwiA SS genomic background with a BN chromosome 2 introgressedCONSOMIC
  • Genotype test result
  • RGD SS-2BN/Mcwi strain report
  • SS-3BN/McwiA SS genomic background with a BN chromosome 3 introgressed.CONSOMIC
  • Genotype test result
  • RGD SS-3BN/Mcwi strain report
  • SS-4BN/McwiA SS genomic background with a BN chromosome 4 introgressed.CONSOMIC
  • Genotype test result
  • RGD SS-4BN/Mcwi strain report
  • SS-5BN/McwiA SS genomic background with a BN chromosome 5 introgressed.CONSOMIC
  • Genotype test result
  • RGD SS-5BN/Mcwi strain report
  • SS-6BN/McwiA SS genomic background with a BN chromosome 6 introgressedCONSOMIC
  • Genotype test result
  • RGD SS-6BN/Mcwi strain report
  • SS-7BN/McwiA SS genomic background with a BN chromosome 7 introgressed.CONSOMIC
  • Genotype test result
  • RGD SS-7BN/Mcwi strain report
  • SS.BN-(D8rat163-D8rat81)/McwiA SS genomic background with a majority BN chromosome 8 introgressed, and it is therefore a congenic. The segment of chromosome 8 that caries the BN extends from D8rat163-D8rat81(SS.BN-(D8rat163-D8rat81)).CONGENIC
  • Genotype test result
  • Detailed genotype of the congenic region.
  • RGD SS.BN-(D8rat163-D8rat81)/Mcwi strain report
  • SS-9BN/McwiA SS genomic background with a BN chromosome 9 introgressed.CONSOMIC
  • Genotype test result
  • RGD SS-9BN/Mcwi strain report
  • SS-10BN/McwiA SS genomic background with a BN chromosome 10 introgressed.CONSOMIC
  • Genotype test result
  • RGD SS-10BN/Mcwi strain report
  • SS-11BN/McwiA SS genomic background with a BN chromosome 11 introgressed.CONSOMIC
  • Genotype test result
  • RGD SS-11BN/Mcwi strain report
  • SS-12BN/McwiA SS genomic background with a BN chromosome 12 introgressed.CONSOMIC
  • Genotype test result
  • RGD SS-12BN/Mcwi strain report
  • SS.BN-(D12arb13-D12rat79)/McwiA SS genomic background with a majority BN chromosome 12 introgressed, and it is therefore a congenic.The segment of chromosome 12 that caries the BN extends from D12arb13 to D12rat79(SS.BN-D12arb13 - D12rat79). This strain is being rederived and the consomic will be phenotyped later in the program.CONGENIC
  • Genotype test result.
  • Detailed genotype of the congenic region.
  • RGD SS.BN-(D12arb13-D12rat79)/Mcwi strain report
  • SS-13BN/McwiA SS genomic background with a BN chromosome 13 introgressed.CONSOMIC
  • Genotype test result
  • RGD SS-13BN/Mcwi strain report
  • SS.BN-(D13Mgh13-D13Mit4)/McwiA SS genomic background with a majority BN chromosome 13 introgressed, and it is therefore a congenic. The segment of chromosome 13 that caries the BN extends from D13Mgh13-D13Mit4(SS.BN-(D13Mgh13-D13Mit4)).CONGENIC
  • Genotype test result.
  • Detailed genotype of the congenic region.
  • RGD SS.BN-(D13Mgh13-D13Mit4)/Mcwi strain report
  • SS-14BN/McwiA SS genomic background with a BN chromosome 14 introgressed.CONSOMIC
  • Genotype test result
  • RGD SS-14BN/Mcwi strain report
  • SS-15BN/McwiA SS genomic background with a BN chromosome 15 introgressed.CONSOMIC
  • Genotype test result
  • RGD SS-15BN/Mcwi strain report
  • SS-16BN/McwiA SS genomic background with a BN chromosome 16 introgressed.CONSOMIC
  • Genotype test result
  • RGD SS-16BN/Mcwi strain report
  • SS-17BN/McwiA SS genomic background with a BN chromosome 17 introgressed.CONSOMIC
  • Genotype test result
  • RGD SS-17BN/Mcwi strain report
  • SS-18BN/McwiA SS genomic background with a BN chromosome 18 introgressed.CONSOMIC
  • Genotype test result)
  • RGD SS-18BN/Mcwi strain report
  • SS-19BN/McwiA SS genomic background with a BN chromosome 19 introgressed.CONSOMIC
  • Genotype test result
  • RGD SS-19BN/Mcwi strain report
  • SS-20BN/McwiA SS genomic background with a BN chromosome 20 introgressed.CONSOMIC
  • Genotype test result
  • RGD SS-20BN/Mcwi strain report
  • SS-XBN/McwiA SS genomic background with a BN chromosome X introgressed.CONSOMIC
  • Genotype test result
  • .
  • RGD SS-XBN/Mcwi strain report
  • SS-YBN/McwiA SS genomic background with a BN chromosome Y introgressed.CONSOMIC
  • Genotype test result
  • RGD SS-YBN/Mcwi strain report
  • FHH-1BN/McwiA FHH genomic background with a BN chromosome 1 introgressed.CONSOMIC
  • Genotype Test Result
  • .
  • RGD FHH-1BN/Mcwi strain report
  • FHH-2BN/McwiA FHH genomic background with a BN chromosome 2 introgressed.CONSOMIC
  • Genotype Test Result
  • .
  • RGD FHH-2BN/Mcwi strain report
  • FHH-3BN/McwiA FHH genomic background with a BN chromosome 3 introgressed.CONSOMIC
  • Genotype Test Result
  • .
  • RGD FHH-3BN/Mcwi strain report
  • FHH-4BN/McwiA FHH genomic background with a BN chromosome 4 introgressed.CONSOMIC
  • Genotype Test Result
  • .
  • RGD FHH-4BN/Mcwi strain report
  • FHH-5BN/McwiA FHH genomic background with a BN chromosome 5 introgressed.CONSOMIC
  • Genotype Test Result
  • .
  • RGD FHH-5BN/Mcwi strain report
  • FHH-6BN/McwiA FHH genomic background with a BN chromosome 6 introgressed.CONSOMIC
  • Genotype Test Result
  • .
  • RGD FHH-6BN/Mcwi strain report
  • .
    FHH-7BN/McwiA FHH genomic background with a BN chromosome 7 introgressed.CONSOMIC
  • Genotype Test Result
  • .
  • RGD FHH-7BN/Mcwi strain report
  • FHH-8BN/McwiA FHH genomic background with a BN chromosome 8 introgressed.CONSOMIC
  • Genotype Test Result
  • .
  • RGD FHH-8BN/Mcwi strain report
  • FHH-9BN/McwiA FHH genomic background with a BN chromosome 9 introgressed.CONSOMIC
  • Genotype Test Result
  • .
  • RGD FHH-9BN/Mcwi strain report
  • FHH-10BN/McwiA FHH genomic background with a BN chromosome 10 introgressed.CONSOMIC
  • Genotype Test Result
  • .
  • RGD FHH-10BN/Mcwi strain report
  • FHH-11BN/McwiA FHH genomic background with a BN chromosome 11 introgressed.CONSOMIC
  • Genotype Test Result
  • .
  • RGD FHH-11BN/Mcwi strain report
  • FHH-12BN/McwiA FHH genomic background with a BN chromosome 12 introgressed.CONSOMIC
  • Genotype Test Result
  • .
  • RGD FHH-12BN/Mcwi strain report
  • FHH-13BN/McwiA FHH genomic background with a BN chromosome 13 introgressed.CONSOMIC
  • Genotype Test Result
  • .
  • RGD FHH-13BN/Mcwi strain report
  • FHH-14BN/McwiA FHH genomic background with a BN chromosome 14 introgressed.CONSOMIC
  • Genotype Test Result
  • .
  • RGD FHH-14BN/Mcwi strain report
  • FHH-15BN/McwiA FHH genomic background with a BN chromosome 15 introgressed.CONSOMIC
  • Genotype Test Result
  • .
  • RGD FHH-15BN/Mcwi strain report
  • FHH-16BN/McwiA FHH genomic background with a BN chromosome 16 introgressed.CONSOMIC
  • Genotype Test Result
  • .
  • RGD FHH-16BN/Mcwi strain report
  • .
    FHH-17BN/McwiA FHH genomic background with a BN chromosome 17 introgressed.CONSOMIC
  • Genotype Test Result
  • RGD FHH-17BN/Mcwi strain report
  • .
    FHH-18BN/McwiA FHH genomic background with a BN chromosome 18 introgressed.CONSOMIC
  • Genotype Test Result
  • .
  • RGD FHH-18BN/Mcwi strain report
  • FHH-19BN/McwiA FHH genomic background with a BN chromosome 19 introgressed.CONSOMIC
  • Genotype Test Result
  • .
  • RGD FHH-19BN/Mcwi strain report
  • FHH-20BN/McwiA FHH genomic background with a BN chromosome 20 introgressed.CONSOMIC
  • Genotype Test Result
  • .
  • RGD FHH-20BN/Mcwi strain report
  • FHH-XBN/McwiA FHH genomic background with a BN chromosome X introgressed.CONSOMIC
  • Genotype Test Result
  • .
  • RGD FHH-XBN/Mcwi strain report
  • FHH-YBN/McwiA FHH genomic background with a BN chromosome Y introgressed.CONSOMIC
  • Genotype Test Result
  • .
  • RGD FHH-YBN/Mcwi strain report