ENU Strain Description


We have completed two consomic panels (44 strains), whereby a BN chromosome was systematically introgressed onto the background of either the SS or FHH rat strains (URL). To complement these resources and data, we are generating ENU-induced mutant strains in the same three parental rat strains. ENU mutant rats are being generated using ENU mutagenesis and screening 100 genes involved in NHLBI disorders, using the TILLING method to identify offspring with the mutated gene of interest. We will test the functionality of these genes by using a broad phenotypic screen of the cardiovascular and pulmonary systems.
The genes selected for mutation screening have been derived from those that have been linked to heart, lung and blood disorders using molecular genetic, genomic and expression technologies during the first four years of all PGA programs. As genomic background is shown to play a major role in the expression of phenotypes in KO mice, this PGA are attempting to make the KOs in 3 genetic backgrounds in the rat, the SS, BN, and FHH strains. The selection of these 3 strains will also enable PhysGen to leverage the enormous amount of phenotypic data generated on these strains during the first four years, notably 8,610 physiological data points per strain, including baseline and stressors, providing an unprecedented level of baseline data for a mutagenesis screen. Click here for details.

Nomenclature Links

RGD Rats Nomenclature Standards

JAX Rat Nomenclature Standards

RGD Genome Scanner

Human Nomenclature Standards



ENU Strain:

  • Click on Allele Symbol to view mutant on the Rat GBrowser.
  • Click on Gene Symbol to view RGD Gene Report.
    ENU Strain NameAllele SymbolStrain TypeGene ReportGene LocationReferences & Links
    F344-AbatTn(sb-T2/Bart3)2.163McwiAbatTn(sb-T2/Bart3)2.163McwiENUAbatChr:10:7040725-7137154RGD Strain Report
    RGD Allele Report
    FHH-Adipoqm1McwiAdipoqm1McwiENUAdipoqChr:11:79908291-79921105RGD Strain Report
    RGD Allele Report
    FHH-Adipoqm2McwiAdipoqm2McwiENUAdipoqChr:11:79908291-79921105RGD Strain Report
    RGD Allele Report
    FHH-Adipoqm3McwiAdipoqm3McwiENUAdipoqChr:11:79908291-79921105RGD Strain Report
    RGD Allele Report
    FHH-Adra1am1McwiAdra1am1McwiENUAdra1aChr:15:46173408-46263607RGD Strain Report
    RGD Allele Report
    FHH-Agtr1bm1McwiAgtr1bm1McwiENUAgtr1bChr:2:105503269-105602591RGD Strain Report
    RGD Allele Report
    FHH-Ccr2m1McwiCcr2m1McwiENUccr2Chr::-RGD Strain Report
    RGD Allele Report
    SS-Cpt2m1McwiCpt2m1McwiENUCpt2Chr:5:129007685-129025501RGD Strain Report
    RGD Allele Report
    F344-DccTn(sb-T2/Bart3)2.205McwiDccTn(sb-T2/Bart3)2.205McwiENUDccChr:18:68026795-69140741RGD Strain Report
    RGD Allele Report
    FHH-Egln3m1McwiEgln3m1McwiENUEgln3Chr:6:74451038-74476506RGD Strain Report
    RGD Allele Report
    F344-Rbed1Tn(sb-T2/Bart3)2.42McwiElmod3Tn(sb-T2/Bart3)2.42McwiENURbed1Chr:4:105866419-106099850RGD Strain Report
    RGD Allele Report
    F344-Erbb4Tn(sb-T2/Bart3)2.208McwiErbb4Tn(sb-T2/Bart3)2.208McwiENUErbb4 Chr:9:66843898-67967970RGD Strain Report
    RGD Allele Report
    FHH-F10m1McwiF10m1McwiENUF10Chr:16:81327237-81346544RGD Strain Report
    RGD Allele Report
    FHH-F10m2McwiF10m2McwiENUF10Chr:16:81327237-81346544RGD Strain Report
    RGD Allele Report
    F344-Fam19a2Tn(sb-T2/Bart3)2.184McwiFam19a2Tn(sb-T2/Bart3)2.184McwiENUFam19a2Chr:7:63388665-63566226RGD Strain Report
    RGD Allele Report
    F344-Fam5cTn(sb-T2/Bart3)2.189McwiFam5cTn(sb-T2/Bart3)2.189McwiENUFam5cChr:13:60584348-61024200RGD Strain Report
    RGD Allele Report
    FHH-Ghsrm1McwiGhsrm1McwiENUGhsrChr:2:113269623-113272999RGD Strain Report
    RGD Allele Report
    SS-Ghsrm3McwiGhsrm3McwiENUGhsrChr:2:113269623-11327299RGD Strain Report
    RGD Allele Report
    FHH-Htr1am1McwiHtr1am1McwiENUHtr1aChr:2:36355683-RGD Allele Report
    F344-Inpp4bTn(sb-T2/Bart3)2.143McwiInpp4bTn(sb-T2/Bart3)2.143McwiENUInpp4bChr:19:27722430-28347305RGD Strain Report
    RGD Allele Report
    F344-Kif16bTn(sb-T2/Bart3)2.200McwiKif16bTn(sb-T2/Bart3)2.200McwiENUKif16bChr:3:130967268-131250402RGD Strain Report
    RGD Allele Report
    SS-Klf4m3McwiKlf4m3McwiENUKlf4Chr:5:73446928-73451286RGD Strain Report
    RGD Allele Report
    FHH-Lcatm1McwiLcatm1McwiENULcatChr:19:35781503-35784980RGD Strain Report
    RGD Allele Report
    BN-Lcatm3McwiLcatm3McwiENULcatChr:19:35781503-35784980RGD Strain Report
    RGD Allele Report
    F344-Lims1Tn(sb-T2/Bart3)2.169McwiLims1Tn(sb-T2/Bart3)2.169McwiENULims1Chr:20:37346411-37456019RGD Strain Report
    RGD Allele Report
    F344-Myo9aTn(sb-T2/Bart3)2.186McwiMyo9aTn(sb-T2/Bart3)2.186McwiENUMyo9aChr:8:63578001-63783806RGD Strain Report
    RGD Allele Report
    FHH-Nr0b2m1McwiNr0b2m1McwiENUNr0b2Chr:5:151524685-151528000RGD Strain Report
    RGD Allele Report
    FHH-Nr4a1m1McwiNr4a1m1McwiENUNr4a1Chr:7:140012807-140020590RGD Strain Report
    RGD Allele Report
    F344-Nrg1Tn(sb-T2/Bart3)2.183McwiNrg1Tn(sb-T2/Bart3)2.183McwiENUNrg1Chr:16:63937796-64126187RGD Strain Report
    RGD Allele Report
    F344-Plcb3Tn(sb-T2/Bart3)2.69McwiPlcb3Tn(sb-T2/Bart3)2.69McwiENUPlcb3Chr:1:209628425-209643694RGD Strain Report
    RGD Allele Report
    F344-Plce1Tn(sb-T2/Bart3)2.146McwiPlce1Tn(sb-T2/Bart3)2.146McwiENUPlce1Chr:1:242794858-243103437RGD Strain Report
    RGD Allele Report
    FHH-Procm1McwiProcm1McwiENUProcChr:18:24563368-24573715RGD Strain Report
    RGD Allele Report
    FHH-Slc8a2m1McwiSlc8a2m1McwiENUSlc8a2Chr:1:76473938-76498626RGD Strain Report
    RGD Allele Report
    SS-Sod3m1McwiSodm1McwiENUSod3Chr:14:63381447-63387180RGD Strain Report
    RGD Allele Report
    F344-Stxbp5lTn(sb-T2/Bart3)2.202McwiStxbp5lTn(sb-T2/Bart3)2.202McwiENUStxbp5lChr:11:65128201-65455115RGD Strain Report
    RGD Allele Report
    BN-Tgfbr2m1McwiTgfbr2m1McwiENUTgfbr2Chr:8:120593595-120680453RGD Strain Report
    RGD Allele Report
    FHH-Tgfbr2m2McwiTgfbr2m1McwiENUTgfbr2Chr:8:120593595-120680453RGD Strain Report
    RGD Allele Report
    FHH-Tlr4m1McwiTlr4m1McwiENUTlr4Chr:5:83564100-83577735RGD Strain Report
    RGD Allele Report
    F344-Trpc4Tn(sb-T2/Bart3)2.192McwiTrpc4Tn(sb-T2/Bart3)2.192McwiENUTrpc4Chr:2:143304929-143485813RGD Strain Report
    RGD Allele Report