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Thank you for visiting the PhysGen Program for Genomic Applications website. Although the program officially came to an end on July 31, 2009, access to the data and tools will continue. In addition to continued access to the data through the PhysGen website, the Rat Genome Database will provide continued updates to the rat strains and phenotype data.

The final PhysGen data release includes phenotype data for 15 Sleeping Beauty mutants. Data is available for FHH, BN and SS ENU strains as well as the Sleeping Beauty mutants. For a current list of available Sleeping Beauty mutants, please visit the Knock Out Rat Consortium. The new PhysGen Knockout program (Mechanistic characterization of genes for hypertension and renal disease, 1RC2HL101681, funded by the National Heart, Lung, and Blood Institute) began on September 30, 2009. This new program aims to develop 100 KO strains using the novel zinc finger nuclease strategy (Geurts et al., Science, 2009, 325(5939):433) and phenotypically characterize 20 strains to investigate the mechanistic relationship between the genes and known mechanisms of hypertension and renal disease.

For questions about availability of rat strains, please contact Mindy Dwinell, Ph.D. (mrdwinel@mcw.edu).

 

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